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1

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

Shuwen He, Peter H. Dobbelaar, Jian Liu, Tianying Jian, Iyassu K. Sebhat, Linus S. Lin, Allan Goodman, Cheng Guo, Peter R. Guzzo, Mark Hadden, Alan J. Henderson, Megan Ruenz, Bruce J. Sargent, Larry Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 560 KB

english, 2010

2

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Raman K. Bakshi, James P. Dellureficio, Qingmei Hong, Nancy N

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 454 KB

english, 2010

3

Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity

Jian Liu, Shuwen He, Tianying Jian, Peter H. Dobbelaar, Iyassu K. Sebhat, Linus S. Lin, Allan Goodman, Cheng Guo, Peter R. Guzzo, Mark Hadden, Alan J. Henderson, Kevin Pattamana, Megan Ruenz, Bruce J

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 927 KB

english, 2010

4

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

Qingmei Hong, Raman K. Bakshi, James Dellureficio, Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Rui Tang, Rubana N. Kalyani, Tanya MacNeil, Aura

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 293 KB

english, 2010

5

Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Raman K. Bakshi, James P. Dellureficio, Qingmei Hong, David H

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.94 MB

english, 2010

6

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4′-piperidine] based melanocortin subtype-4 receptor agonists

Liangqin Guo, Zhixiong Ye, Jian Liu, Shuwen He, Raman K. Bakshi, Iyassu K. Sebhat, Peter H. Dobbelaar, Qingmei Hong, Tianying Jian, James P. Dellureficio, Nancy N. Tsou, Richard G. Ball, David H. Wein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

7

Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity

Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Raman K. Bakshi, Qingmei Hong, James P. Dellureficio, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Mikhail

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

8

Facile one-pot method for the synthesis of novel glycosylidene-based quinolines

Peter H. Dobbelaar, Cecilia H. Marzabadi

Journal:

Tetrahedron Letters

Year:

2010

Language:

english

File:

PDF, 239 KB

english, 2010

9

Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid

Shuwen He, C. Scott Shultz, Zhong Lai, Ronsar Eid, Peter H. Dobbelaar, Zhixiong Ye, Ravi P. Nargund

Journal:

Tetrahedron Letters

Year:

2011

Language:

english

File:

PDF, 336 KB

english, 2011

10

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

He, Shuwen, Ye, Zhixiong, Truong, Quang, Shah, Shrenik, Du, Wu, Guo, Liangqin, Dobbelaar, Peter H., Lai, Zhong, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, Ja

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

11

Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist

Pasternak, Alexander, Feng, Zhe, de Jesus, Reynalda, Ye, Zhixiong, He, Shuwen, Dobbelaar, Peter, Bradley, Scott A., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina

Journal:

ACS Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 901 KB

english, 2012

12

ChemInform Abstract: Povarov Reactions of exo-Glycals: Preparation of C-Linked, Quinoline Analogues.

Peter H. Dobbelaar, Cecilia H. Marzabadi

Journal:

Year:

2012

File:

PDF, 34 KB

2012

13

Povarov reactions of exo-glycals: preparation of C-linked, quinoline analogues

Peter H. Dobbelaar, Cecilia H. Marzabadi

Journal:

Year:

2011

Language:

english

File:

PDF, 654 KB

english, 2011

14

Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity

Xiao-Ming Guan, Howard Chen, Peter H. Dobbelaar, Yan Dong, Tung M. Fong, Karen Gagen, Judith Gorski, Shuwen He, Andrew D. Howard, Tianying Jian, Michael Jiang, Yanqing Kan, Theresa M. Kelly, Jennifer

Journal:

Cell Metabolism

Year:

2010

Language:

english

File:

PDF, 1.60 MB

english, 2010

15

Fear of blushing: fearful preoccupation irrespective of facial coloration

Sandra Mulkens, Peter J. de Jong, Annemiek Dobbelaar, Susan M. Bögels

Journal:

Behaviour Research and Therapy

Year:

1999

Language:

english

File:

PDF, 129 KB

english, 1999

16

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

He, Shuwen, Lai, Zhong, Ye, Zhixiong, Dobbelaar, Peter H., Shah, Shrenik K., Truong, Quang, Du, Wu, Guo, Liangqin, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio,

Journal:

ACS Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 302 KB

english, 2014

17

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Shah, Shrenik K., He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yan

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.84 MB

english, 2015

18

SAR Exploration at the C-3 Position of Tetrahydro-β-carboline sstr3 Antagonists

He, Shuwen, Dobbelaar, Peter H., Guo, Liangqin, Ye, Zhixiong, Liu, Jian, Jian, Tianying, Truong, Quang, Shah, Shrenik K., Du, Wu, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James D., S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 683 KB

english, 2016

19

Energy-efficient solar photochemistry with Luminescent Solar Concentrator-based photomicroreactors

Cambie, Dario, Dobbelaar, Jeroen, Riente Paiva, Paola, Vanderspikken, Jochen, Shen, Chong, Seeberger, Peter, Gilmore, Kerry, Debije, Michael, Noel, Timothy

Journal:

Angewandte Chemie International Edition

Year:

2019

Language:

english

File:

PDF, 976 KB

english, 2019

20

Energy‐efficient solar photochemistry with Luminescent Solar Concentrator‐based photomicroreactors

Cambie, Dario, Dobbelaar, Jeroen, Riente Paiva, Paola, Vanderspikken, Jochen, Shen, Chong, Seeberger, Peter, Gilmore, Kerry, Debije, Michael, Noel, Timothy

Journal:

Angewandte Chemie

Year:

2019

Language:

english

File:

PDF, 977 KB

english, 2019